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Thus, further research is desperately needed to determine whether direct GLP-1 action in the MRS can modulate of drug taking and seeking and do so in the absence of nausea/malaise (discussed in further detail below)
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Moreover, progress continues in studies designed to overcome leptin resistance, as exemplified by the concomitant administration of the pentacyclic triterpene celastrol, which enhances leptin sensitivity through mechanisms requiring interleukin 1 receptor 1 [97]
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